Rachel SmithChoosing cosmetic injectables is a personal decision, especially when your goal is not to look “done,” but to look refreshed, rested, and naturally confident.
For expertly treated frown lines and expression wrinkles, the best Botox in Indianapolis is available at trusted clinics that prioritize subtle, natural-looking results.
I have taken the time to research the local aesthetic landscape with a focus on providers who prioritize safety, facial balance, and results that enhance rather than change your features.
This guide highlights top-rated clinics that specialize in subtle facial rejuvenation and take the time to explain the differences between Botox, fillers, and other injectables.
Each practice brings a distinct philosophy to treatment, making it easier to find a provider whose approach aligns with your goals for natural, age-appropriate results.
How much does Botox cost in Indianapolis?
In the Indianapolis area, you can generally expect to pay between $10 and $15 per unit of neurotoxin. Most patients treating common areas, such as the forehead or crow’s feet, typically see a total bill ranging from $300 to $600, depending on the volume required.
While some high-end clinics might offer flat-rate pricing for specific anatomical zones, per-unit pricing remains the standard throughout the region. Moreover, it is helpful to inquire about “beauty banking” or monthly membership programs.
Many local practices offer these financial arrangements to help lower the per-unit cost for regular clients. Maintaining your results becomes more predictable and affordable over the long term, allowing for consistent care without unexpected spikes in pricing during follow-up visits.
1. Ageless Aesthetics
Website: https://agelessindy.com/
Address: 8860 Zionsville Rd #300c
Contact: +1 317-855-9100
Clinic Hours:
- Mon: 10:00 AM – 5:00 PM
- Tue – Wed & Fri: 9:00 AM – 5:00 PM
- Thu: 9:00 AM – 7:00 PM
Ageless Aesthetics is designed for adults who want to soften wrinkles, smooth expression lines, and achieve natural-looking rejuvenation without looking overdone.
Their signature “Holy Trifecta” approach goes beyond a quick injection by combining expertly placed neurotoxin treatments with medical-grade skincare and collagen stimulation to support long-term skin health.
This makes it an ideal choice for individuals comparing Botox, fillers, or other injectables and seeking results that enhance their features while still looking like themselves.
Board-certified injectors apply a deep understanding of facial anatomy to deliver subtle, balanced outcomes.
Clients also benefit from a dedicated patient app that simplifies appointment management and allows real-time tracking of Beauty Banking rewards, along with thoughtful perks such as birthday bonus units.
One important consideration is the Forever Flawless membership, which requires a six-month commitment. While this structure benefits those planning regular treatments, it may feel like a larger step for patients who are new to aesthetic services.
Customer Reviews:
She listens to your needs and slays them!
I highly recommend Ashley Grant. She listens to your needs and slays them! Thank you for helping me feel and look amazing, for my 50th birthday!
- Sara Nielander | Google Review
I highly recommend Ageless Aesthetics!
I had a great experience with Shelley! I am a needle freak and usually pass out. She was super patient and I didn’t even feel a thing. I highly recommend Ageless aesthetics!
- Ella Queisser | Googe Review
2. Laser and Skin Surgery Center of Indiana
Website: https://thelassi.com/
Address: 8925 N Meridian St # 200
Contact: +1 317-660-4900
Clinic Hours: Mon – Fri: 7:15 AM – 4:00 PM
For those seeking a clinical setting supported by strong academic credibility, this center stands out as an excellent option for aesthetic care.
Led by Dr. C. William Hanke, a triple board-certified dermatologist, this facility serves as a primary site for clinical research trials for products like Botox and Juvederm.
As a result, patients get access to treatments straight from the source of medical innovation. My visit was smooth and efficient, and the staff called me back right on time for my appointment.
The facility holds the distinction of being the first accredited office-based surgical facility in the state of Indiana, which ensures that safety protocols are rigorous and unmatched.
The only notable drawback is the single location on North Meridian, which may involve a longer commute depending on your neighborhood.
However, the high level of expertise and the peace of mind provided by their credentials make the drive worthwhile. Plus, the environment is strictly professional, prioritizing clinical outcomes and safety over a traditional spa-like feel.
Customer Reviews:
Each visit was beyond my expectations
Dr Hanke, Dr McCoy, Caitlin and Nettie were all very attentive, professional and committed to providing an excellent patient experience. This was my third Mohs Surgery at this facility. Each visit was beyond my expectations.
- Doug Goodman | Google Review
Doctor Brogan has a very well-organized practice
Doctor Brogan has a very well organized practice. I arrived early; was called in early and quickly seen by the doctor. His examination was thorough, and explained clearly. All in all, this was a much better experience than I expected.
- David Kelly | Google Review
3. Lyfe Aesthetics & MedSpa
Website: https://mylyfemedspa.com/
Address: 3965 N Meridian St Suite C
Contact: +1 317-600-3217
Clinic Hours:
- Tue & Fri: 9:00 AM – 7:00 PM
- Wed, Thu & Sat: 9:00 AM – 5:00 PM
Lyfe Aesthetics focuses on helping adults smooth fine lines and wrinkles while still looking like themselves, not overdone.
It’s ideal for those exploring options like Botox, fillers, or other injectables and who want a subtle, natural refresh rather than a dramatic change.
The clinic offers a private, boutique experience in a quiet, secure setting that appeals to clients who value discretion and calm.
Every treatment begins with an inside-out philosophy, where skin health, facial balance, and overall wellness are considered together, helping you make informed decisions when comparing rejuvenation options.
Their advanced technology, including picosecond pulse devices, supports skin renewal while preserving natural expression.
Plus, care is led by licensed medical professionals, including a Doctor of Nursing Practice, with clear guidance and realistic recovery timelines.
To maintain this personalized experience, walk-in availability is limited, and appointments should be scheduled in advance, so you have to consider this if you want to avail their treatments.
Customer Reviews:
The spa was super cute and had very zen vibes.
Thank you so much for taking such great care of me. The spa was super cute and very zen vibes. I barely even felt the injections and left looking 10 years younger!! Lifetime client here, HIGHLY recommend 🖤
- Tisha Louella | Google Review
Sarah is super sweet, knowledgeable, and supportive.
Sarah is super sweet, knowledgeable, and supportive and she provided great advice to this relative newbie. She was able to adjust my injectable to avoid the harsh appearance I’ve gotten from a different provider before. Highly recommend!
- Hannah Meils-Bracken | Google Review
4. Rejhuvenation Aesthetics
Website: https://www.vagaro.com/rejhuvenationaesthetics
Address: 5221 E Thompson Rd
Contact: +1 463-253-4364
Clinic Hours:
- Mon & Wed – Fri: 9:00 AM – 7:00 PM
- Tue & Sat: 9:00 AM – 5:00 PM
Rejhuvenation Aesthetics is ideal for adults who want to soften fine lines and wrinkles while maintaining a natural, refreshed appearance.
It is especially well-suited for those comparing Botox, fillers, and other injectables or exploring facial rejuvenation for the first time.
As a fully bilingual medspa, services are offered in both English and Spanish to ensure comfort and clarity throughout the experience.
On top of that, the team’s background as former ICU and NICU nurses is reflected in their careful technique, strong safety standards, and calming bedside manner.
Clients can choose from four neurotoxin options, including Botox, Xeomin, Jeuveau, and Dysport, allowing treatments to be tailored to individual facial structure and goals.
Complimentary consultations also help clients feel informed and confident before moving forward.
Appointments are limited to specific days, which can be inconvenient for clients with tight or unpredictable schedules, even though membership options help make ongoing maintenance more structured and easier to plan.
Customer Reviews:
I am so satisfied with the results
Jho is so sweet and kind, she made me feel so comfortable and right at home! It felt like I was catching up with a friend 🙂 I am so satisfied with the results, almost all my forehead wrinkles are gone and it’s only been one week! I get married in 2 months and I feel so much more confident and beautiful. I will be back for more and can’t wait to see her again!
- Remi Wise | Google Review
She is definitely someone you can trust
Jho was amazing to work with! She walked me through everything and answered all my questions (and there were a lot)! I was so happy with my results. She is definitely someone you can trust to do what’s best for you and your specific needs.
- Melissa Moreau | Google Review
5. Pure Image Laser and Spa
Website: https://pureimagelaserandspa.com/
Address: 8350 S Emerson Ave Suite 120
Contact: +1 317-820-5288
Clinic Hours:
- Mon – Thu: 10:00 AM – 8:00 PM
- Fri: 10:00 AM – 4:00 PM
Pure Image Laser and Spa is ideal for adults who want to soften wrinkles and expression lines while maintaining a natural, refreshed appearance.
For those comparing Botox, fillers, or other injectables and feeling unsure about what will look best, this women-owned practice offers reassurance through expertise and education.
The injectors here do more than treat patients. They also train other medical professionals in advanced injection techniques and safety standards, reflecting a high level of skill and precision.
The clinic itself is impeccably clean and welcoming, creating a calm, comfortable experience from the moment you arrive.
Beyond neurotoxins and fillers, they also offer wellness-focused treatments like NAD+ restoration, which you don’t usually see at traditional medspas.
Another highlight worth noting is their loyalty programs, which allow clients to combine in-house VIP perks with Alle and Aspire rewards.
Keep in mind that Friday afternoon appointment availability is limited, so planning ahead is recommended.
Customer Reviews:
Prices are great and Emily is the best!
Started my botox journey here over a year ago and I look forward to every appointment with Emily! Staff is always friendly. The office is always clean and cozy. Prices are great and Emily is the best!
- Tiffany Ballard | Google Review
Such friendly staff and a very clean spa!
I would highly recommend Niki if you are looking for a facial! It was first time at Pure Image Laser and Spa and it won’t be my last. Such friendly staff and a very clean spa! Thank you for making me feel so comfortable with my whole experience!
- Erin Bryant | Google Review
